Risk of hepatitis B virus transmission by diagnostic hysteroscopy

Risk of hepatitis B virus transmission by diagnostic hysteroscopy

Blog Article

Few data are available in the literature concerning the efficacy of standard hysteroscope disinfection procedures to prevent hepatitis B transmission.The aim of the present study was to determine the risk of hepatitis B virus (HBV) transmission during hysteroscopy among anti-HBc-seropositive women.Serum and hysteroscopic samples were collected from 62 women after diagnostic hysteroscopy.All samples were tested for serologic HBV markers.Polymerase chain reactions (PCR) were carried out to amplify regions C and S of the viral genome and only samples amplified by both pairs of primers were considered to be positive.

Anti-HBc Pre-Rolls was repeatedly reactive in 48 (77%) of 62 serum samples, and HBsAg was detected in 8 (13%).At least one HBV serologic marker was found in 49 (79%) samples.Only one sample was HBsAg positive and anti-HBc negative.HBV-DNA was detected by PCR in 7 serum samples but in only 3 hysteroscopic samples obtained just after hysteroscopy.It is noteworthy that high levels of anti-HBc IgM were detected in one HBsAg-negative patient who showed an HBV-DNA-positive hysteroscopic Kratom Liquids sample.

An elevated sample/cut-off ratio for anti-HBc IgM suggests recent infection and reinforces the need for testing for HBsAg and anti-HBc before hysteroscopy, since acute hepatitis B can be clinically asymptomatic.Viral DNA was not detected in any hysteroscopic samples collected after washing and disinfecting procedures with glutaraldehyde.We conclude that HBV-DNA can be found in the hysteroscope soon after hysteroscopy, but standard disinfecting procedures are effective in viral removal.